Until 2007: The originality of the approach I have undertaken to synthesize and study nanomaterials was to jointly control the morphology, the size distribution, the nature of the interfaces and the stoichiometry of the products. Indeed, many controversies in literature come from the non-control of one of these parameters (evolution of the lattice parameters, phase transition temperatures…). Some of these controversies have thus been excluded thanks to the approach I have developed.
After 2007 (after my habilitation): I refocused my work to initiate, in my laboratory, a new thematic about bioapplications of nanopowders.
Founder of the Research Team (Bio-)hybrid nanoparticles & nanostructures BH2N
The key nanomaterials studied are:
- SPIONs (SuperParamagnetic Iron Oxide Nanoparticles) for multimodal imaging (MRI/PET and MRI/optical imaging). Two strengths are put to use (i) the originality of their simultaneous synthesis and colloidal stabilization in one step through a hydrothermal synthesis device working continuously (synthesis time <10 s, conditions T, P up to the supercritical water field) and (ii) the association of these nanoparticles with innovative chelating agents (NODAGA, MANOTA etc.) or innovative fluorophores (phtalocyanine in particular).
- Titanate nanotubes (TiONts) that few teams in the world are able to synthesize. For the first time, these nanoparticles are developed for applications related to their ability to be internalized in various cell types. They have proven themselves for DNA transfection and radiosensitizing of tumors (glioblastoma and prostate cancer).
- Curriculum Vitae (English)
Administration
- Deputy Director of ICB lab
- Elected member of the Research Council and of the Conseil Académique of the Université de Bourgogne(since 2020)
- Elected member of the Conseil Académique of the Université Bourgogne Franche-Comté (since 2020)
- Member of the steering committee of the C’Nano Grand-Est (since 2018)
- Member of the steering committee of the C’Nano France (since 2018)
- Selection Committee Chair for Chemistry of the University of Burgundy 31/32/33 sections
- Member of the scientific committee of the GIS Pharmaco-Imagery (since its creation in 2016)
- Member of the BFCare cluster (since 2008)
- Elected member of CNU, section 31 (alternate) (in 2015-2016)
- Expert of the ANR agency, of the F.R.S.-FNRS (Belgium) and of several universities
Member of the National and Local Organizing Committees of The SFNano – C’Nano joint meeting 2019
207 communications:
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- 34 invited conferences (19 in international congresses)
- 14 invited seminars (6 abroad)
- 13 popular science lectures (with personal invitation)
Awards:
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- European Ceramic Society award (Brighton, UK), 1998
- French Ceramic Society award (Paris, France), 1998
- JECH award (Paris, France, Heterogeneous Kinetic), 1998
Principal investigator and founder of the national training action ANF NanoMed 2018
Member of the scientific committee of ICONAN 2016, 2017 and 2018
Some upcoming or recent communications:
- Development of novel versatile theranostic platforms based on titanate nanotubes: new safe nanovectors for drugs, plasmid DNA and imaging probes, F. Salem, A. Loiseau, A.L. Papa, J. Boudon, N. Millot*, 12th Meeting on Nanoscience Advances, 15-17 septembre 2021, Porquerolles (France), Invited conference
- Nanoparticles and human health : State of the art about risks and benefits International Symposium on New Technologies and Advanced Therapies of Health, N. Millot*, 21-23 October 2019, Bogota (Colombia) Invited conference
- Development of novel versatile theranostic platforms: from SPIONs to titanate nanotubes and tantalum oxides, J. Boudon, L. Maurizi, F. Sallem, N. Millot*, SFNano, Montpellier (France), 3-5 décembre 2018
- Continuous and reproducible functionalized nanoparticles as MRI-PET contrast agents: towards targeting multimodal probes? G. Thomas, J. Boudon, L. Maurizi, M. Moreau, P. Walker, A. Oudot, F. Demoisson, F. Denat, F. Brunotte, N. Millot*, BioNanomed, 20-22 mars 2017, Krems (Austria)
- Researcher unique identifiers:
Google Scholar
ORCID
Researcher ID
Scopus
- Guest Editor of the current Special Issues:
Molecules (IF 4.411): Advances in Metal Oxide Nanoparticles
Nanomaterials (IF 5.076): Advanced Studies in Nano-BioAnalytical Physico-Chemistry
- 2018: Guest Editor of a Special issue of Nanomaterials (20 papers published)
> Special Issue “Biomedical Applications of Nanoparticles” (+ printed edition)
- 1 international patent “Titanate nanostructures for regenerative medicine and tissue engineering“, WO 2014/079890 A1 Millot Nadine, Vandroux David, Bellat Vanessa
- 14 conference proceedings (two of them referenced by Sci. Finder Scholar)
- 3 book chapters:
* Nanomedicine (One Central Press, UK 2014) “Titanate nanotubes as a versatile platform for nanomedicine” J. Boudon, A.L. Papa, J. Paris, N. Millot* Unraveling the Safety Profile of Nanoscale Particles and Materials – From Biomedical to Environmental Applications, Edited by Andreia C. Gomes and Marisa P. Sarria, InTech – open science, 2018 ISBN 978-953-51-3940-9, Published: March 21, 2018 “Toxicological risk assessment of emerging nanomaterials: cytotoxicity, cellular uptake, effects on biogenesis and cell organelle activity, acute toxicity and biodistribution of oxide nanoparticles” L. Maurizi, A.L. Papa, J. Boudon, S. Sruthi, B. Pruvot, D. Vandroux, J. Chluba, G. Lizard, N. Millot, Chapter 2,
- * “New Trends in Macromolecular and Supramolecular Chemistry for Biomedical Applications” Springer Nature Switzerland, November 2020 “Development of novel versatile theranostic platforms based on titanate nanotubes: towards safe nanocarriers for biomedical applications” J. Boudon, F. Sallem, A. Loiseau, L. Maurizi, A.-L. Papa, N. Millot
- 1 popular article: “Nanoparticules : de nouveaux outils thérapeutiques déjà éprouvés. Danger ou formidable espoir pour la société ?” N. Millot, Réalités Pédiatriques – n° 207_Janvier 2017
Relevant publications of the last years:
- “In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?“, N. Singh, C. Marets, J. Boudon, N. Millot, L. Saviot, L. Maurizi, Review Nanoscale Advances (January 2021) Lien hypertexte
- Inside front cover
- “Antiplatelet effect induced by iron oxide nanoparticles: correlation with conformational change in fibrinogen“, R. K. Kottana, L. Maurizi, B. Schnoor, K. Morris, N. Millot, A.L. Papa, Small (December 2020) Lien hypertexte
- Back cover
- “Radiotherapy enhancement in prostate cancer treatment by titanate nanotubes engineered with gold nanoparticles and docetaxel“, A. Loiseau, J. Boudon, A. Oudot, M. Moreau, R. Boidot, R. Chassagnon, N.M. Saïd, S. Roux, C. Mirjolet and N. Millot*, Cancers 11(12), 1962 (21 pages) (2019) Lien hypertexte
- “Elaboration of transresveratrol derivative-loaded superparamagnetic iron oxide nanoparticles for glioma treatment”, F. Sallem, D. Vervandier-Fasseur, T. Nury, L. Maurizi, J. Boudon, G. Lizard, N. Millot, Nanomaterials 9, 287 (20 pages) (2019) Lien hypertexte
- “Cellular interactions of functionalized superparamagnetic iron oxide nanoparticles on oligodendrocytes without detrimental side effects: cell death induction, oxidative stress and inflammation”, S. Sruthi, L. Maurizi, T. Nury, F. Sallem, J. Boudon, J. M. Riedinger, N. Millot, F. Bouyer, G. Lizard, Colloids and Surfaces B 170, 454-462 (2018) Lien hypertexte
- “Taxane-grafted metal-oxide nanoparticles as a new theranostic tool against cancer: the promising example of docetaxel-functionalized titanate nanotubes in preclinical development on prostate tumors“, A. Loiseau, J. Boudon, C. Mirjolet, G. Créhange, N. Millot, Adv. Healthcare Mater. 6 (16), 1700245 (2017) Lien hypertexte
- “One-step continuous synthesis of functionalized magnetite nanoflowers“, G. Thomas, F. Demoisson, R. Chassagnon, E. Popova, N. Millot, Nanotechnology 27, 135604-135619 (2016) Lien hypertexte
Principal advisor of International Relations of ESIREM, Materials Department
Principal advisor of ESIREM internships, Materials Department (2006-2021)
Control of the placement of 55 students each year, co-writing of a quality charter on internships, advice for students, personal placement of 5 to 10 students each year, administrative follow-up of internships, choice of the tutors at the university, organization of the oral defenses.
Teaching duties 2020/2021:
- ESIREM 2nd and 3rd years, “Cristallography”, Lecture (19,5 h), Tutorial (31,5 h)
- ESIREM 4th and 5th years, “Responsability of internships and international relations” (40 h)
- ESIREM 4th and 5th years, “Ceramic”, Tutorial (6 h), Practical Work (20 h)
- ESIREM 5th year, “The impact of nanomaterials on Health and Safety”, Lecture (5h)
- BSc in Chemistry (Licence 3), “Nanopowders”, Lecture (11 h)
- Graduate school EIPHI Contrôle et Durabilité des Matériaux
“The impact of nanomaterials on Health and Safety”, Lecture (8 h)
“Nanohybrids: Biomedical Applications”, Lecture (4 h)
- M2 international LipTherapI, Lecture (2h)
Author of an educational book, Lavoisier Editions (Paris, February 2014) “Cristallographie Géométrique – Cours – Exercices et Problèmes corrigés” (266 pages), Nadine MILLOT, Jean-Claude NIEPCE, Graduate-level, Engineering school