Annuaire

Until 2007: The originality of the approach I have undertaken to synthesize and study nanomaterials was to jointly control the morphology, the size distribution, the nature of the interfaces and the stoichiometry of the products. Indeed, many controversies in literature come from the non-control of one of these parameters (evolution of the lattice parameters, phase transition temperatures…). Some of these controversies have thus been excluded thanks to the approach I have developed.

After 2007 (after my habilitation): I refocused my work to initiate, in my laboratory, a new thematic about bioapplications of nanopowders.

Founder of the Research Team (Bio-)hybrid nanoparticles & nanostructures BH2N

The key nanomaterials studied are:

• SPIONs (SuperParamagnetic Iron Oxide Nanoparticles) for multimodal imaging (MRI/PET and MRI/optical imaging). Two strengths are put to use (i) the originality of their simultaneous synthesis and colloidal stabilization in one step through a hydrothermal synthesis device working continuously (synthesis time <10 s, conditions T, P up to the supercritical water field) and (ii) the association of these nanoparticles with innovative chelating agents (NODAGA, MANOTA etc.) or innovative fluorophores (phtalocyanine in particular).
• Titanate nanotubes (TiONts) that few teams in the world are able to synthesize. For the first time, these nanoparticles are developed for applications related to their ability to be internalized in various cell types. They have proven themselves for DNA transfection and radiosensitizing of tumors (glioblastoma and prostate cancer).
• Curriculum Vitae (English)

Administration

• Deputy Director of ICB lab
• Elected member of the Research Council and of the Conseil Académique of the Université de Bourgogne(since 2020)
• Elected member of the Conseil Académique of the Université Bourgogne Franche-Comté (since 2020)
• Member of the steering committee of the C’Nano Grand-Est (since 2018)
• Member of the steering committee of the C’Nano France (since 2018)

• Selection Committee Chair for Chemistry of the University of Burgundy 31/32/33 sections
• Member of the scientific committee of the GIS Pharmaco-Imagery (since its creation in 2016)
• Member of the BFCare cluster (since 2008)
• Elected member of CNU, section 31 (alternate) (in 2015-2016)
• Expert of the ANR agency, of the F.R.S.-FNRS (Belgium) and of several universities

• * 2022/2024: Responsible of one WP in the ANR project UFO “Up-conversion Ferroelectric nanocrystals for Optical sensing of electric field in biological systems“. In collaboration with ENS-PS, Centrale Supélec, CEA.
  
• * 2021/2023: Co-principal investigator of a project funded by ISITE BFC: Peroxisomal and mitochondrial targeting with multifunctional nanoparticles: towards new treatments of neurodegenerative diseases. In collaboration with BioPeroxIL
  
• * 2020/2023: Co-principal investigator of a project funded by Région BFC and EUR EIPHI: Functionalized nanoparticles intended to target biological vesicles within a complex sample for sorting by standing acoustic waves within a microsystem. NPs@EVs  project is in collaboration with Femto-ST
• *2019/2022: Responsible of one theme in the NanoNeuroMed project: Caractérisation à l’échelle NANOscopique des maladies NEUROdégénératives et solutions thérapeutiques issues des nanosciences : applications en MEDecine funded by Région BFC and EUR EIPHI
• * 2010/2019: Principal investigator of a scientific project supported by joint funds through the CNRS/Burgundy Council/University of Burgundy trilateral agreement: 3MIM (“Marquage de Molécules par les Métaux pour l’Imagerie Médicale”, in English “Labelling of Molecules with Metals for Medical Imaging”) followed by PARI2 Pharmaco-Imagerie project, Project: “Multifonctionnal nanomaterials for biomedical applications”:
  This project involves collaborative efforts from 19 researchers spread over three laboratories of the Université de Bourgogne (ICB, ICMUB, LE2I), two hospitals (CHU de Dijon and CGFL) and a biotechnology company (NVH Medicinal)
• * Since 2012: Principal investigator and founder of “Bourgogne-Nanocare” platform, Satt Grand Est (Welience), in collaboration with BioPeroxIL, &INSERM U866: development of cytotoxicity assays, genotoxicity assays, DCFDA cellular ROS detection assays, ecotoxicity assays (Zebrafish), biodistribution studies (MRI, PET, SPECT, OI) to evaluate nanoparticle toxicity or safety profile

> Nanocare platform

• * Since 2011: Principal investigator of a thematic in the Equipex IMAPPI (Integrated Magnetic resonance And Positron emission tomography in Preclinical Imaging) funded by the General Commission for Investment and the French Government- One scientific project in progress for the development of bimodal contrast agents based on SPIONs (MRI/PET)

> Equipex IMAPPI

• * 2015/2017: Principal investigator of two projects with the radiotherapy department of the French Comprehensive Cancer Center
  “Titanate nanotubes as new nanovectors of radiosensitizers: internalization, radiosensitizing and biodistribution of these nanohybrids, vectors of docetaxel, in case of prostate cancers in nude mouse model ” (co-principal investigator Prof. G. Créhange). Project funded by the Cancer League “Grand-Est” (2012/2013)
  “Nanohybrids based on titanate nanotubes and gold nanoparticles as new radiosensitizers of prostate cancer”. Project funded by the Greater East Cancer Research Clusters
• * Principal investigator of an agreement with the biotechnology company NVH Medicinal (signed in 2010 for 4 years and renewed in 2015). Scientific topic: nanoparticles, proteins and regenerative medicine

> NVH Medical

• * 2014/2019: Principal investigator of a scientific theme inside PARI2 Nano2Bio: “Nanoparticles for the vectorization of drugs and for regenerative medicine”

Member of the National and Local Organizing Committees of The SFNano – C’Nano joint meeting 2019

207 communications:

• • 34 invited conferences (19 in international congresses)
  • 14 invited seminars (6 abroad)
  • 13 popular science lectures (with personal invitation)

Awards:

• • European Ceramic Society award (Brighton, UK), 1998
  • French Ceramic Society award (Paris, France), 1998
  • JECH award (Paris, France, Heterogeneous Kinetic), 1998

Principal investigator and founder of the national training action ANF NanoMed 2018

Member of the scientific committee of ICONAN 2016, 2017 and 2018

Some upcoming or recent communications:

• Development of novel versatile theranostic platforms based on titanate nanotubes: new safe nanovectors for drugs, plasmid DNA and imaging probes, F. Salem, A. Loiseau, A.L. Papa, J. Boudon, N. Millot*, 12th Meeting on Nanoscience Advances, 15-17 septembre 2021, Porquerolles (France), Invited conference
• Nanoparticles and human health : State of the art about risks and benefits International Symposium on New Technologies and Advanced Therapies of Health, N. Millot*, 21-23 October 2019, Bogota (Colombia) Invited conference
• Development of novel versatile theranostic platforms: from SPIONs to titanate nanotubes and tantalum oxides, J. Boudon, L. Maurizi, F. Sallem, N. Millot*, SFNano, Montpellier (France), 3-5 décembre 2018
• Continuous and reproducible functionalized nanoparticles as MRI-PET contrast agents: towards targeting multimodal probes? G. Thomas, J. Boudon, L. Maurizi, M. Moreau, P. Walker, A. Oudot, F. Demoisson, F. Denat, F. Brunotte, N. Millot*, BioNanomed, 20-22 mars 2017, Krems (Austria)

• Researcher unique identifiers:

Google Scholar

ORCID

Researcher ID

Scopus

• Guest Editor of the current Special Issues:

Molecules (IF 4.411): Advances in Metal Oxide Nanoparticles

Nanomaterials (IF 5.076): Advanced Studies in Nano-BioAnalytical Physico-Chemistry

• 2018: Guest Editor of a Special issue of Nanomaterials (20 papers published)

> Special Issue “Biomedical Applications of Nanoparticles” (+ printed edition)

• 1 international patent “Titanate nanostructures for regenerative medicine and tissue engineering“, WO 2014/079890 A1 Millot Nadine, Vandroux David, Bellat Vanessa
• 14 conference proceedings (two of them referenced by Sci. Finder Scholar)
• 3 book chapters:

* Nanomedicine (One Central Press, UK 2014) “Titanate nanotubes as a versatile platform for nanomedicine” J. Boudon, A.L. Papa, J. Paris, N. Millot* Unraveling the Safety Profile of Nanoscale Particles and Materials – From Biomedical to Environmental Applications, Edited by Andreia C. Gomes and Marisa P. Sarria, InTech – open science, 2018 ISBN 978-953-51-3940-9, Published: March 21, 2018 “Toxicological risk assessment of emerging nanomaterials: cytotoxicity, cellular uptake, effects on biogenesis and cell organelle activity, acute toxicity and biodistribution of oxide nanoparticles” L. Maurizi, A.L. Papa, J. Boudon, S. Sruthi, B. Pruvot, D. Vandroux, J. Chluba, G. Lizard, N. Millot, Chapter 2,

• * “New Trends in Macromolecular and Supramolecular Chemistry for Biomedical Applications” Springer Nature Switzerland, November 2020 “Development of novel versatile theranostic platforms based on titanate nanotubes: towards safe nanocarriers for biomedical applications” J. Boudon, F. Sallem, A. Loiseau, L. Maurizi, A.-L. Papa, N. Millot
• 1 popular article: “Nanoparticules : de nouveaux outils thérapeutiques déjà éprouvés. Danger ou formidable espoir pour la société ?” N. Millot, Réalités Pédiatriques – n° 207_Janvier 2017

Relevant publications of the last years:

• “In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?“, N. Singh, C. Marets, J. Boudon, N. Millot, L. Saviot, L. Maurizi, Review Nanoscale Advances (January 2021) Lien hypertexte
• Inside front cover
• “Antiplatelet effect induced by iron oxide nanoparticles: correlation with conformational change in fibrinogen“, R. K. Kottana, L. Maurizi, B. Schnoor, K. Morris, N. Millot, A.L. Papa, Small (December 2020) Lien hypertexte
•   Back cover
• “Radiotherapy enhancement in prostate cancer treatment by titanate nanotubes engineered with gold nanoparticles and docetaxel“, A. Loiseau, J. Boudon, A. Oudot, M. Moreau, R. Boidot, R. Chassagnon, N.M. Saïd, S. Roux, C. Mirjolet and N. Millot^*, Cancers 11(12), 1962 (21 pages) (2019) Lien hypertexte
• “Elaboration of transresveratrol derivative-loaded superparamagnetic iron oxide nanoparticles for glioma treatment”, F. Sallem, D. Vervandier-Fasseur, T. Nury, L. Maurizi, J. Boudon, G. Lizard, N. Millot, Nanomaterials 9, 287 (20 pages) (2019) Lien hypertexte
• “Cellular interactions of functionalized superparamagnetic iron oxide nanoparticles on oligodendrocytes without detrimental side effects: cell death induction, oxidative stress and inflammation”, S. Sruthi, L. Maurizi, T. Nury, F. Sallem, J. Boudon, J. M. Riedinger, N. Millot,  F. Bouyer, G. Lizard, Colloids and Surfaces B 170, 454-462 (2018) Lien hypertexte
  
• “Taxane-grafted metal-oxide nanoparticles as a new theranostic tool against cancer: the promising example of docetaxel-functionalized titanate nanotubes in preclinical development on prostate tumors“, A. Loiseau, J. Boudon, C. Mirjolet, G. Créhange, N. Millot, Adv. Healthcare Mater. 6 (16), 1700245 (2017) Lien hypertexte
• “One-step continuous synthesis of functionalized magnetite nanoflowers“, G. Thomas, F. Demoisson, R. Chassagnon, E. Popova, N. Millot, Nanotechnology 27, 135604-135619 (2016) Lien hypertexte

Principal advisor of International Relations of ESIREM, Materials Department

Principal advisor of ESIREM internships, Materials Department (2006-2021)

Control of the placement of 55 students each year, co-writing of a quality charter on internships, advice for students, personal placement of 5 to 10 students each year, administrative follow-up of internships, choice of the tutors at the university, organization of the oral defenses.

Teaching duties 2020/2021: 

• ESIREM 2nd and 3rd years, “Cristallography”, Lecture (19,5 h), Tutorial (31,5 h)
• ESIREM 4th and 5th years, “Responsability of internships and international relations” (40 h)
• ESIREM 4th and 5th years, “Ceramic”, Tutorial (6 h), Practical Work (20 h)
• ESIREM 5th year, “The impact of nanomaterials on Health and Safety”, Lecture (5h)
• BSc in Chemistry (Licence 3), “Nanopowders”, Lecture (11 h)
• Graduate school EIPHI Contrôle et Durabilité des Matériaux
  “The impact of nanomaterials on Health and Safety”, Lecture (8 h)
  “Nanohybrids: Biomedical Applications”, Lecture (4 h)
• M2 international LipTherapI, Lecture (2h)

Author of an educational book, Lavoisier Editions (Paris, February 2014) “Cristallographie Géométrique – Cours – Exercices et Problèmes corrigés” (266 pages), Nadine MILLOT, Jean-Claude NIEPCE, Graduate-level, Engineering school