Annuaire

Resume:

I studied Physics at Université de Bourgogne (uB), where I got a master degree in Nanotechnology and Nanobiosciences in 2009. I earned a PhD from uB in 2012 under the supervision of Professor Patrick Senet. I was postdoctoral research associate at Renselaer Poytechnic Institute (NY, USA) in 2013-2014, joining the group of Professor Vincent Meunier and at Ecole Polytechnique Federale de Lausanne (Switzerland) in the group of Professor Clémence Corminboeuf (LCMD) until 2015 when I joined uB as an assistant professor.

Research interests:

My domains of expertise are condensed matter physics, physics and chemistry of nanomaterials and biophysics. My research uses computational approaches, numerical simulations and machine learning to examine and describe mechanisms of interactions between nanomaterials and biological molecules (proteins) at the atomic level. I am particularly interested in the characterisation and detection of single biomolecules using devices based on nanomaterials (spectroscopic and sequencing techniques).

  https://www.sayens-materiaux-technologies.fr/modelisation-moleculaire

2024:

• Single-Molecule, Sensors and Nanosystems (Paris, October 28-30th 2024): Sequencing of α-Synuclein Intrinsically Disordered Protein through single-layer MoS2 Solid-State Nanopores.

• JTMS2024 “Journées Théorie, Modélisation et Simulation 2024” (Toulouse, October 8-9th): Structural analysis of the Drosophila Melanogaster GSTome.

• ComplexBioDyn2024 (Dijon, June 9-14th 2024): MoS2 Solid-State Nanopores as Single-Biomolecule Sensors.

• Nanofluidics Conference (Lenzerheide, Jan. 21-24th 2024): Single-layer MoS2 Nanopores for Coarse-Grained Sequencing of Proteins

2023:

• Single-Molecule Sensors and nanoSystems International Conference 2023 (Barcelona, Nov. 23rd 2023): Single-layer MoS2 Nanopores for Coarse-Grained Sequencing of Proteins

• Black Forest Nanopore Meeting (Nov. 6-9th 2023): Single-layer MoS2 Nanopores for Coarse-Grained Sequencing of Proteins
• 1ère réunion de l’axe transverse “Expériences numériques, modélisations et intelligence artificielle” (Dijon, July 13th 2023): SEPIA : Nano-SEquenceur de Protéines assisté par Intelligence Artificielle
• Rencontre des Chimistes Théoriciens du Grand-Est (Reims, May 30-31st 2023): Functional modes and thermal B-factor predictions for multigenic structural analysis predicted from AlphaFold
• GGMM 2023 – Young Modellers Conference (Toulouse, May 17th 2023): Functional modes and thermal B-factor predictions for multigenic structural analysis predicted from AlphaFold
• GGMM 2023 – Young Modellers Conference (Toulouse, May 17th 2023): Identification of the Twenty Proteinogenic Amino Acids using MoS2 Solid-State Nanopores
• 1ère réunion de l’axe transverse “Matériaux innovants et Photonique pour la Santé” (Dijon, April 27th 2023): Nanodetection and neurodegenerative diseases

2022:

• 2022 MRS Fall meeting and exhibit (Boston USA, December 1st 2022): Identification of Proteinogenic Amino Acids using MoS2 Solid-State Nanopores

2021:

• Bioelectrodynamics Webinar series (December 6th 2021): Challenges in unlabelled single-biomolecule sequencing using 2-D solid–state nanopores

• NanoMedicine International Conference 2021 (Milan Italy Oct. 20-22 2021): Nanopore Sensing of Single-Biomolecule: Challenges in Protein Sequencing using Solid-State Nanopores.
• Nanopore Weekly Meeting (Webinar Sept. 13th 2021): Challenges in Protein Sequencing using 2-D MoS2 Nanopores.
• The International Society of Quantum Biology and Pharmacology (ISQBP) 2021 President’s Meeting (Online June 29th-July 1st 2021): Challenges in Protein Sequencing using 2-D MoS2 Nanopores, Answers from all-atom Molecular Dynamics.

2019:

• The SFNano C’Nano joint meeting (Dijon France, Dec. 10-12 2019): Identifying Patterns in Time Series Data: Application to Biological Peptide Translocation through single-layer MoS2 Nanopores.
• International Conference on Advanced Nanotechnology and Nanomaterials (Dubaï UAE, Nov. 20-21): Identifying Patterns in Time Series Data: Application to Biological Peptide Translocation through single-layer MoS₂ Nanopores.

2018:

• Reportage FR3 BFC: https://france3-regions.francetvinfo.fr/bourgogne-franche-comte/chercheurs-universite-bourgogne-veulent-revolutionner-dessalement-eau-mer-1449241.html
• Materials Research Society Fall Meeting (Boston USA, Nov. 25-30): Modeling the Ionic Conductivity and Biomolecule Translocation Through Solid-State MoS₂ Nanopores

2017: 

• Deciphering complex energy landscape and kinetic network from single molecules to cells: a new challenge to make theories meet experiments (Dijon France Sept. 3-8 2017): Computational investigation of the translocation of single polypeptide through MoS2 nanopores from ionic conductance dynamics.
• XXVIII International Materials Research Congress (Cancún México, Aug. 20-25): Biological Peptide Sequencing: Computational investigation of the performances of MoS₂ solid-state nanopores for such applications.

2024:

• Journal of Physical Chemistry: Molecular Dynamics of Peptide Sequencing through MoS2 Solid-State Nanopores for Binary Encoding Applications
• Biomolecules: Structural Analysis of the Drosophila melanogaster
• Biomolecules: Structural and Thermodynamic Insights into Dimerization Interfaces of Drosophila Glutathione Transferases
• Carbon: Molecular Dynamics Simulations of 2D-layered Graphene Sheets with Tandem Repeat Proteins

2023 :

• Frontiers in Nanotechnology: Single-layer MoS2 Solid-State Nanopores for Coarse-Grained Sequencing of Proteins
• FEBS Letters: Structure–activity analysis suggests an olfactory function for the unique antennal delta glutathione transferase of Apis mellifera
• Molecules: Einstein Model of a Graph to Characterize Protein Folded/Unfolded States
• Biomolecules: Role of Insect and Mammal Glutathione Transferases in Chemoperception

2022 :

• Applied Science: Free-Energy Landscape Analysis of Protein-Ligand Binding: The Case of Human Glutathione Transferase A1
• Frontiers in Molecular Biosciences: Wild-Type α-Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation.
• Single Molecule Sensing Beyond Fluorescence (Springer): Challenges in Protein Sequencing Using 2-D MoS2 Nanopores

2021:

• Frontiers in Molecular Biosciences: Missense Mutations Modify the Conformational Ensemble of the α-Synuclein Monomer Which Exhibits a Two-Phase Characteristic

2020:

• Nanoscale: Nanopore Sensing of Single-Biomolecule: A New Procedure to Identify Protein Sequence Motifs from Molecular Dynamics.
• The Journal of Physical Chemistry B: Curvature and torsion of protein main chain as local order parameters of protein unfolding

2019:

• The Journal of Physical Chemistry B: Molecular Dynamics Investigation of Polylysine Peptide Translocation through MoS₂ Nanopores.
• Applied Physics Letter: Improved model of ionic transport in 2-D MoS₂ membranes with sub-5 nm pores.
• Chemistry–A European Journal: On‐Surface Synthesis and Characterization of Acene‐Based Nanoribbons Incorporating Four‐Membered Rings.
• Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes (Springer): Raman and Infrared Spectra of Acoustical, Functional Modes of Proteins from All-Atom and Coarse-Grained Normal Mode Analysis.

2018:

• Insect Biochemistry and Molecular Biology: Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification.
• Nano Letters: Angstrom-Size Defect Creation and Ionic Transport through Pores in Single-Layer MoS₂.

2017:

• WSEAS Trans. Circuits Syst: Computational investigation of the ionic conductance through molybdenum disulfide (MoS2) nanopores.
• Journal of the American Chemical Society: On-Surface Cyclization of ortho-Dihalotetracenes to Four- and Six-Membered Rings.
• Journal of Materials Chemistry C: Charge transport in highly ordered organic nanofibrils: lessons from modelling.
• Chemical Science: Photochromic Torsional Switch (PTS): a light-driven actuator for the dynamic tuning of π-conjugation extension.

2016:

• Journal of Physical Chemistry Letters: Theoretical Insights into Sub-Terahertz Acoustic Vibrations of Proteins Measured in Single-Molecule Experiments.
• Journal of Computational Chemistry: Beyond static structures: Putting forth REMD as a tool to solve problems in computational organic chemistry.
• Carbon: Structural, energetic, and electronic properties of gyroidal graphene nanostructures.
• ACS Omega: Fingerprints of conformational states of human Hsp70 at sub-THz frequencies.

2015:

• Journal of Physical Chemistry Letters: Exploiting dispersion-driven aggregators as a route to new one-dimensional organic nanowires.
• ACS Nano: On-surface synthesis of BN-substituted heteroaromatic networks.
• ACS Applied Materials & Interfaces: Temperature-dependent and bistable current–voltage measurements in zinc porphyrin molecular junctions.
• The Journal of Physical Chemistry C: Electrolyte Diffusion in Gyroidal Nanoporous Carbon.
• Scientific Reports: Intrinsic localized modes in proteins.
• ACS Nano: DNA translocation in nanometer thick silicon nanopores.

2014:

• Accounts of Chemical Research: Interfacial properties and design of functional energy materials.
• Physical Chemistry Chemical Physics: Tunable water desalination across graphene oxide framework membranes.

2013:

• PLOS Computational Biology: Decipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.
• Journal of Chemical Theory and Computation: Molecular dynamics simulations of graphene oxide frameworks.
• Journal of Biomolecular Structure and Dynamics: Conformational dynamics of full-length inducible human Hsp70 derived from microsecond molecular dynamics simulations in explicit solvent.
• Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes (Springer): Low-Frequency, Functional, Modes of Proteins: All-Atom and Coarse-Grained Normal Mode Analysis.

2010:

• Journal of Chemical Theory and Computation: Human inducible Hsp70: structures, dynamics, and interdomain communication from all-atom molecular dynamics simulations.

Licence Sciences et Techniques :

• L1: Physique Générale
• L2: Outils Informatiques pour la Physique et la Chimie
• L3: Physique de la Matière Condensée et Introduction à la Physique Statistique

Master Physics Photonics Nanotechnology :

• M1: Soft Matter (Practical)
• M2: Nanobiomodelling (Practical)

Master Santé :

• M1: Bioinformatique au service de la décarbonation