Annuaire

Résumé:

I studied Physics at the University of Burgundy, where I obtained a Master’s degree in Nanotechnology and Nanobiosciences in 2009. I completed my PhD at the same university in 2012 under the supervision of Professor Patrick Senet. Following this, I worked as a postdoctoral research associate at Rensselaer Polytechnic Institute (NY, USA) in 2013–2014 with Professor Vincent Meunier (2D materials), and later at the École Polytechnique Fédérale de Lausanne (Switzerland) in the group of Professor Clémence Corminboeuf (Laboratory for Computational Molecular Design). In 2015, I joined the University of Burgundy as an Assistant Professor.

Research interests:

My areas of expertise include condensed matter physics, nanomaterials physics and chemistry, as well as biophysics and bioinformatics. My research focuses on using computational approaches, numerical simulations, and machine learning to investigate and elucidate the mechanisms governing interactions between nanomaterials and biological molecules (particularly proteins) at the atomic scale. I am especially interested in the characterization and detection of single biomolecules using nanomaterial-based devices, with applications in spectroscopy and sequencing technologies.

  https://www.sayens-materiaux-technologies.fr/modelisation-moleculaire

2025:

• Phonons dans les milieux complexes (Lyon, June 10-11th): Acoustical modes of nanobioparticles.
• GGMM 2025 (Forges les eaux, June 10-12th): In Silico Design and Prediction of Structural Properties of Dimerization Interfaces of Drosophila Melanogaster Gluthatione Transferases.
• C’Nano 2025: The Nanoscience Meeting (Paris, March 18-20th): MoS2 Solid-State Nanopores as Single-BioMolecule Sensors.

2024:

• Single-Molecule, Sensors and Nanosystems (Paris, October 28-30th 2024): Sequencing of α-Synuclein Intrinsically Disordered Protein through single-layer MoS2 Solid-State Nanopores.

• JTMS2024 “Journées Théorie, Modélisation et Simulation 2024” (Toulouse, October 8-9th): Structural analysis of the Drosophila Melanogaster GSTome.

• ComplexBioDyn2024 (Dijon, June 9-14th): MoS2 Solid-State Nanopores as Single-Biomolecule Sensors.

• Nanofluidics Conference (Lenzerheide, Jan. 21-24th): Single-layer MoS2 Nanopores for Coarse-Grained Sequencing of Proteins

2023:

• Single-Molecule Sensors and nanoSystems International Conference 2023 (Barcelona, Nov. 23rd): Single-layer MoS2 Nanopores for Coarse-Grained Sequencing of Proteins

• Black Forest Nanopore Meeting (Nov. 6-9th): Single-layer MoS2 Nanopores for Coarse-Grained Sequencing of Proteins
• 1ère réunion de l’axe transverse “Expériences numériques, modélisations et intelligence artificielle” (Dijon, July 13th): SEPIA : Nano-SEquenceur de Protéines assisté par Intelligence Artificielle
• Rencontre des Chimistes Théoriciens du Grand-Est (Reims, May 30-31st): Functional modes and thermal B-factor predictions for multigenic structural analysis predicted from AlphaFold
• GGMM 2023 – Young Modellers Conference (Toulouse, May 17th): Functional modes and thermal B-factor predictions for multigenic structural analysis predicted from AlphaFold
• GGMM 2023 – Young Modellers Conference (Toulouse, May 17th): Identification of the Twenty Proteinogenic Amino Acids using MoS2 Solid-State Nanopores
• 1ère réunion de l’axe transverse “Matériaux innovants et Photonique pour la Santé” (Dijon, April 27th): Nanodetection and neurodegenerative diseases

2022:

• 2022 MRS Fall meeting and exhibit (Boston USA, December 1st): Identification of Proteinogenic Amino Acids using MoS2 Solid-State Nanopores

2021:

• Bioelectrodynamics Webinar series (December 6th): Challenges in unlabelled single-biomolecule sequencing using 2-D solid–state nanopores

• NanoMedicine International Conference 2021 (Milan Italy Oct. 20-22nd): Nanopore Sensing of Single-Biomolecule: Challenges in Protein Sequencing using Solid-State Nanopores.
• Nanopore Weekly Meeting (Webinar Sept. 13th): Challenges in Protein Sequencing using 2-D MoS2 Nanopores.
• The International Society of Quantum Biology and Pharmacology (ISQBP) 2021 President’s Meeting (Online June 29th-July 1st): Challenges in Protein Sequencing using 2-D MoS2 Nanopores, Answers from all-atom Molecular Dynamics.

2019:

• The SFNano C’Nano joint meeting (Dijon France, Dec. 10-12): Identifying Patterns in Time Series Data: Application to Biological Peptide Translocation through single-layer MoS2 Nanopores.
• International Conference on Advanced Nanotechnology and Nanomaterials (Dubaï UAE, Nov. 20-21): Identifying Patterns in Time Series Data: Application to Biological Peptide Translocation through single-layer MoS₂ Nanopores.

2018:

• Reportage FR3 BFC: https://france3-regions.francetvinfo.fr/bourgogne-franche-comte/chercheurs-universite-bourgogne-veulent-revolutionner-dessalement-eau-mer-1449241.html
• Materials Research Society Fall Meeting (Boston USA, Nov. 25-30): Modeling the Ionic Conductivity and Biomolecule Translocation Through Solid-State MoS₂ Nanopores

2017: 

• Deciphering complex energy landscape and kinetic network from single molecules to cells: a new challenge to make theories meet experiments (Dijon France Sept. 3-8): Computational investigation of the translocation of single polypeptide through MoS2 nanopores from ionic conductance dynamics.
• XXVIII International Materials Research Congress (Cancún México, Aug. 20-25): Biological Peptide Sequencing: Computational investigation of the performances of MoS₂ solid-state nanopores for such applications.

2025:

• ACS Applied Nano Materials: Sequencing of α-synuclein Intrinsically Disordered Protein in MoS₂ Nanopores
• chemRχiv: Local Entropy in Proteins

2024:

• Journal of Physical Chemistry: Molecular Dynamics of Peptide Sequencing through MoS2 Solid-State Nanopores for Binary Encoding Applications
• Biomolecules: Structural Analysis of the Drosophila melanogaster
• Biomolecules: Structural and Thermodynamic Insights into Dimerization Interfaces of Drosophila Glutathione Transferases
• Carbon: Molecular Dynamics Simulations of 2D-layered Graphene Sheets with Tandem Repeat Proteins

2023 :

• Frontiers in Nanotechnology: Single-layer MoS2 Solid-State Nanopores for Coarse-Grained Sequencing of Proteins
• FEBS Letters: Structure–activity analysis suggests an olfactory function for the unique antennal delta glutathione transferase of Apis mellifera
• Molecules: Einstein Model of a Graph to Characterize Protein Folded/Unfolded States
• Biomolecules: Role of Insect and Mammal Glutathione Transferases in Chemoperception

2022 :

• Applied Science: Free-Energy Landscape Analysis of Protein-Ligand Binding: The Case of Human Glutathione Transferase A1
• Frontiers in Molecular Biosciences: Wild-Type α-Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation.
• Single Molecule Sensing Beyond Fluorescence (Springer): Challenges in Protein Sequencing Using 2-D MoS2 Nanopores

2021:

• Frontiers in Molecular Biosciences: Missense Mutations Modify the Conformational Ensemble of the α-Synuclein Monomer Which Exhibits a Two-Phase Characteristic

2020:

• Nanoscale: Nanopore Sensing of Single-Biomolecule: A New Procedure to Identify Protein Sequence Motifs from Molecular Dynamics.
• The Journal of Physical Chemistry B: Curvature and torsion of protein main chain as local order parameters of protein unfolding

2019:

• The Journal of Physical Chemistry B: Molecular Dynamics Investigation of Polylysine Peptide Translocation through MoS₂ Nanopores.
• Applied Physics Letter: Improved model of ionic transport in 2-D MoS₂ membranes with sub-5 nm pores.
• Chemistry–A European Journal: On‐Surface Synthesis and Characterization of Acene‐Based Nanoribbons Incorporating Four‐Membered Rings.
• Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes (Springer): Raman and Infrared Spectra of Acoustical, Functional Modes of Proteins from All-Atom and Coarse-Grained Normal Mode Analysis.

2018:

• Insect Biochemistry and Molecular Biology: Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification.
• Nano Letters: Angstrom-Size Defect Creation and Ionic Transport through Pores in Single-Layer MoS₂.

2017:

• WSEAS Trans. Circuits Syst: Computational investigation of the ionic conductance through molybdenum disulfide (MoS2) nanopores.
• Journal of the American Chemical Society: On-Surface Cyclization of ortho-Dihalotetracenes to Four- and Six-Membered Rings.
• Journal of Materials Chemistry C: Charge transport in highly ordered organic nanofibrils: lessons from modelling.
• Chemical Science: Photochromic Torsional Switch (PTS): a light-driven actuator for the dynamic tuning of π-conjugation extension.

2016:

• Journal of Physical Chemistry Letters: Theoretical Insights into Sub-Terahertz Acoustic Vibrations of Proteins Measured in Single-Molecule Experiments.
• Journal of Computational Chemistry: Beyond static structures: Putting forth REMD as a tool to solve problems in computational organic chemistry.
• Carbon: Structural, energetic, and electronic properties of gyroidal graphene nanostructures.
• ACS Omega: Fingerprints of conformational states of human Hsp70 at sub-THz frequencies.

2015:

• Journal of Physical Chemistry Letters: Exploiting dispersion-driven aggregators as a route to new one-dimensional organic nanowires.
• ACS Nano: On-surface synthesis of BN-substituted heteroaromatic networks.
• ACS Applied Materials & Interfaces: Temperature-dependent and bistable current–voltage measurements in zinc porphyrin molecular junctions.
• The Journal of Physical Chemistry C: Electrolyte Diffusion in Gyroidal Nanoporous Carbon.
• Scientific Reports: Intrinsic localized modes in proteins.
• ACS Nano: DNA translocation in nanometer thick silicon nanopores.

2014:

• Accounts of Chemical Research: Interfacial properties and design of functional energy materials.
• Physical Chemistry Chemical Physics: Tunable water desalination across graphene oxide framework membranes.

2013:

• PLOS Computational Biology: Decipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.
• Journal of Chemical Theory and Computation: Molecular dynamics simulations of graphene oxide frameworks.
• Journal of Biomolecular Structure and Dynamics: Conformational dynamics of full-length inducible human Hsp70 derived from microsecond molecular dynamics simulations in explicit solvent.
• Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes (Springer): Low-Frequency, Functional, Modes of Proteins: All-Atom and Coarse-Grained Normal Mode Analysis.

2010:

• Journal of Chemical Theory and Computation: Human inducible Hsp70: structures, dynamics, and interdomain communication from all-atom molecular dynamics simulations.

Licence Sciences et Techniques :

• L1: Physique Générale
• L2: Outils Informatiques pour la Physique et la Chimie
• L3: Physique de la Matière Condensée et Introduction à la Physique Statistique

Master Physics Photonics Nanotechnology :

• M1: Soft Matter (Practical)
• M2: Nanobiomodelling (Practical)

Master Santé :

• M1: Bioinformatique au service de la décarbonation